Hold’em for Life Oncology Fellowships

Sunnybrook Health Sciences Centre

Project: Rare Mutation Melanoma Trial with Encorafenib and Binimetinib

Princess Margaret Cancer Centre

Project: Cross tumor-comparison of the tumor immune microenvironment, peripheral immune signatures and response to immunotherapy as a novel conceptual model in aerodigestive tumors 

Lunenfeld-Tanenbaum Research Institute

Project: Immune Modulation in Hippo Pathway Regulated Breast Tumour Microenvironments 

Princess Margaret Cancer Centre

Project: Exercise and Rehabilitation for People with Cancer: A Survey of Canadian Oncology Residents’ Knowledge and Awareness of Practice Guidelines

CBRE Hold'em for Life Fellow,
Princess Margaret Cancer Centre

Project: A retrospective review of the use of GCSF for patients with GU receiving chemotherapy during the COVID-19 pandemic and implications for the future

Princess Margaret Cancer Centre

Project: Acquired pharmacologic vulnerabilities in cyclin dependent kinase 4/6 (CDK4/6) inhibitor-resistant hormone receptor positive breast

Princess Margaret Cancer Centre

Project: Profiling of Cancer of Unknown Primary Site, Melanoma, Adnexal, Skin for Optimizing Immunotherapy

Sunnybrook Health Sciences Centre

Project: Detection of Circulating Tumour DNA before and after Stereotactic Ablative Radiotherapy for Confirmed and Suspected Early Lung Cancer (SABR-DETECT) 

Sunnybrook Health Sciences Centre

Project: Reflex MammaPrint and BluePrint testing on breast cancer core biopsies: Impact on tumor phenotype classification, perceived provider utility, and process implementation

Silvercore Hold'em for Life Oncology Fellow,
Princess Margaret Cancer Centre

Project: Development of an early warning system for non-muscle invasive bladder cancer recurrence and progression using time-series forecasting with artificial intelligence

The Hospital for Sick Children

Project: Describing limited English proficiency (LEP) in paediatric oncology

Princess Margaret Cancer Centre

Project: Incidence, prevalence, risk factors and impact of fatty liver disease in metastatic HR+/HER2− breast cancer patients in first line of treatment with Aromatase Inhibitors and CDK 4/6

Princess Margaret Cancer Centre

Project: Does systemic inflammation and sarcopenia impact quality of life and survival in patients with esophageal cancer?

The Hospital for Sick Children

Project: Translational in vivo modeling to identify therapeutic opportunities for high-risk neuroblastoma

Sunnybrook Health Sciences Centre

Project: Stimulated Microbubble Radiation Enhancement Treatment in Head and Neck Cancer Patients

Princess Margaret Cancer Centre

Project: Understanding the gene expression profile of neuroendocrine carcinoma of genitourinary primaries: a pilot study

Princess Margaret Cancer Centre

Project: The impact of AIRE single-nucleotide polymorphisms on the incidence and severity of immune-related adverse events in melanoma patients treated with anti-PD-1-based regimens

Princess Margaret Cancer Centre

Project: Use of targeted therapies in patients with advanced thyroid cancer: efficacy and safety outcomes from a real-world genomically profiled cohort

Princess Margaret Cancer Centre

Project: Improving the Transition to Practice Curriculym in the Medical Oncology Training Program

Lunenfeld-Tanenbaum Research Institute

Project: Deciphering the role of the Formin / Wnt-PCP axis in breast cancer cell motility and Metastasis

The Hospital for Sick Children

Project: DNA-damage response targeting and epigenetic priming to overcome radio-resistance in very high-risk medulloblastoma

Princess Margaret Cancer Centre

Project: Evaluation of plasma minimal residual disease and T cell clonal expansion to guide adjuvant immunotherapy in Stage III NSCLC patients

Princess Margaret Cancer Centre

Project: Phase I Study of Autologous Epithelial Ovarian Cancer (EOC) Cells Containing Lentivirus Engineering Expression of IL-12 

Princess Margaret Cancer Centre

Project: Comprehensive genomic, immunologic and metabolomic characterization of the tumour, host, and gut microbiome interaction in hepatocellular carcinoma

Toronto Western Hospital

Project: Uncovering the epigenetic and transcriptomic biomarkers of response to radiotherapy in meningiomas

Lunenfeld-Tanenbaum Research Institute

Project: Studying DNA damage networks in human cancer cells

Princess Margaret Cancer Centre
Project: Unravelling the potential of extracelular vesicles as biomarkers of intraductal and cribriform prostate cancer

Sunnybrook Health Sciences Centre
Project: Integrating equity into quality metrics for colorectal cancer care: an Analysis of wait times for curative-intent surgery

Lunenfeld-Tanenbaum Research Institute
Project: Development of risk prediction models for early detection and prognosis of aerodigestive cancers

Princess Margaret Cancer Centre
Project: External validation of the VIGEX gene-expression signature as a novel predictive biomarker for immuno-oncology (IO) treatments

Princess Margaret Cancer Centre
Project: miRNAs as potential circulating tumor markers for stratifying and surveilling small testicular masses

Sunnybrook Health Sciences Centre
Project: Toward Immunotherapy in breast cancer brain metastases: PD-L1 expression and beyond

Princess Margaret Cancer Centre
Project: Process Analysis for the HIMALAYAS Study: Cancer Survivor's Experience with a Supervised Cardio-Oncology Rehabilitation Program

Mount Sinai Hospital
Project: Enhancing Prognostication in Colorectal Cancer: the Role of Clinico-pathologic and Molecular Features Beyond the TNM Staging System

The Hospital for Sick Children
Project: Gliomas with DNA-replication repair deficiency: How the cell-of-origin, genomic, and epigenetic landscape impact immune-directed therapeutic vulnerability

Lunenfeld-Tanenbaum Research Institute
Project: A New Therapeutic Strategy for Highly Lethal Small Cell Neuroendocrine Cancers 

Princess Margaret Cancer Centre
Project: Cancer cachexia and genotype correlations in Pancreatic Ductal Adenocarcinoma

Princess Margaret Cancer Centre
Project: Tumor-informed ctDNA dynamics in HR+/HER2- metastatic breast cancer patients receiving first-line CDK4/6 inhibitors

Princess Margaret Cancer Centre
Project: CP-101 and Atezolizumab in Patients with Advanced Solid TumorS to INterrogate the Gut Microbiota (CASSIN)

Mount Sinai Hospital
Project: Molecular Testing of Indeterminate Thyroid Nodules for Informed Surgical Management

Princess Margaret Cancer Centre
Project: Clinico-genetic risk stratification of limited stage follicular lymphoma

Sunnybrook Health Sciences Centre
Project: Contemporary Risk of Bone Fractures Among Men with Advanced Prostate Cancer on Androgen Deprivation Therapy

The Hospital for Sick Children
Project: Harnessing CRISPR to identify drivers of medulloblastoma metastasis

Princess Margaret Cancer Centre
Project: Indocyanine green (ICG) Guided Sentinel Lymph Node Biopsy in Breast Cancer

Sunnybrook Health Sciences Centre
Project: Reflex MammaPrint and BluePrint testing on breast cancer core biopsies: Impact on tumor phenotype classification, perceived provider utility, and process implementation

Princess Margaret Cancer Centre
Project: Characterizing the impact of using novel patient-centered pathology reports in clinical practice

Princess Margaret Cancer Centre
Project: Development of an early warning system for non-muscle invasive bladder cancer recurrence and progression using time-series forecasting with artificial intelligence

Princess Margaret Cancer Centre
Project: Next-Generation Sequencing in Advanced Thyroid Cancers: Clinical Application and Impact on Patient Outcomes

Princess Margaret Cancer Centre
Project: Explainable Artificial Intelligence in the diagnosis of Muscle Invasive Upper Tract Urothelial Carcinoma

Princess Margaret Cancer Centre
Project: Optimizing the Quality of Surveillance in Patients with Completely Resected Gastroenteropancreatic Neuroendocrine Tumours

Princess Margaret Cancer Centre
Project: Machine learning to estimate the real-world risk of 3-year disease free survival in patients with residual, triple negative breast cancer after neoadjuvant chemotherapy

Sunnybrook Health Sciences Centre
Project: Pilot Investigation of Ultrasound Cell Death Imaging and Spectroscopy as Early Indicators of Response to Radiation Treatment in Prostate Cancer

Princess Margaret Cancer Centre
Project: Predicting Response to Neoadjuvant Chemotherapy in Advanced Ovarian Cancer Using the Rate of Elimination of CA-125 (KELIM Score) and Chemo-Response Score

The Hospital for Sick Children
Project: Targeting EZH2 in EBTs: Role of epigenetic modifiers in modulating pluripotency

The Hospital for Sick Children
Project: Characterization of MUC16/CA125 expression in pediatric in pediatric soft-tissue sarcomas and pilot study of a first-in-class MUC16/CA125 T-cell engager bispecific antibody

Princess Margaret Cancer Centre
Project: Study of circulating tumor DNA (ctDNA) kinetics in immuno-oncology (IO-KIN)

Lunenfeld-Tanenbaum Research Institute
Project: Detecting epithelial-mesenchymal transition states in highly multiplexed imaging data

The Hospital for Sick Children
Project: Epigenetic Priming to Overcome Radio-Resistance in Very High-Risk Medulloblastoma

Princess Margaret Cancer Centre
Project: Immune Response to COVID-19 Vaccine in immunotherapy (IO) and non-IO Treated Cancer Patients (VIVACIOUS)

Toronto General Hospital
Project: Age Related Clonal Hematopoiesis and Atherosclerotic Cardiovascular Disease in Cancer Survivors

The Hospital for Sick Children
Project: Mitochondrial Fission: Targeting the Achilles’ Heel of Glioblastoma

Princess Margaret Cancer Centre
Project: Free/Total PSA ratio as a biomarker for PSMA PET positivity in patients with biochemical recurrence post prostatectomy

The Hospital for Sick Children
Project: Characterization of the metabolic drivers of grp3 medulloblastoma metastasis

Sunnybrook Health Sciences Centre
Project: Learning Curves and Volume-Outcome Relationships in Robot-Assisted Surgical Oncology

Princess Margaret Cancer Centre
Project: Identifying molecular vulnerabilities in pancreatic ductal adenocarcinoma

Princess Margaret Cancer Centre
Project: Lung adenocarcinoma brain metastasis prediction and non-invasive diagnosis using methylation signatures in tissue and plasma

Mount Sinai Hospital
Project: Optimizing Sexual Health and Emotional Well-Being got Breast Cancer Patients and Survivors

Mount Sinai Hospital
Project: Venous thromboembolism in hematologic malignancy and hematopoietic cell transplant patients

Princess Margaret Cancer Centre
Project: Seeing Clearly: A Decision Analysis of MRI, PSMA PET/CT, and Biomarker Testing in Early Prostate Cancer Detection

The Hospital for Sick Children
Project: PICTURE: PARP Inhibitors and Chemotherapy for patients harbouring TUmours with homologous REcombination repair deficiency: a phase II pilot study

Mount Sinai Hospital
Project: Clinicopathologic and Molecular Predictors of Outcomes Following Salvage Surgery for Locally Recurrent Rectal Cancer 

Princess Margaret Cancer Centre
Project: Fragility Index of Approved Cancer Drugs 

Princess Margaret Cancer Centre
Project: Nuclear Hexokinase 2: Mechanism of Regulating Stemness in Acute Myeloid Leukemia

Princess Margaret Cancer Centre
Project: Predicting Outcomes in Pancreatic Cancer from Clinical and Genomic Data using Machine Learning

Toronto General Hospital
Project: Enhancing sentinel lymph node mapping in lung cancer surgery using a novel liposome-based dual-modality nanoparticle 

Princess Margaret Cancer Centre
Project: Porphysomes for the intraoperative visualization of colorectal lymph node metastases

Mount Sinai Hospital
Project: The Impact of Critical Illness on Oncology Care Following Critical Care Survival

The Hospital for Sick Children
Project: Children with Cancer as Participants in End-of-life-Research

The Hospital for Sick Children
Project: Harnessing CRISPR to identify drivers of medulloblastoma metastasis 

Princess Margaret Cancer Centre
Project: Comparison of OpeN VErsus RoboTic (CONVERT) Partial Nephrectomy Trial- a feasibility randomized control trial

Princess Margaret Cancer Centre
Project: Machine Learning to estimate risk of 3-year disease-free survival in patients with residual, HER2-positive breast cancer after neoadjuvant chemotherapy and HER2- targeted therapy.

The Hospital for Sick Children
Project: Characterization of the metabolic drivers of grp3 medulloblastoma metastasis

The Hospital for Sick Children
Project: Mitochondrial Fission: Targeting the Achilles' Heel of Glioblastoma 

Princess Margaret Cancer Centre
Project: Application of the Generalizable Frailty Index using population-based health administrative data in older patients with diffuse large B-cell lymphoma (DLBCL), with further sensitivity analyses using a smaller cohort with detailed pathologic and cancer -specific data 

Princess Margaret Cancer Centre
Project: Identifying molecular vulnerabilities in pancreatic cancer 

Mount Sinai Hospital
Project: Optimizing Sexual Health and Emotional Well-Being got Breast Cancer Patients and Survivors

Mount Sinai Hospital
Project: Toward Streamlining Colon Cancer Care

Toronto General Hospital
Project: Characterizing Heart And Mind health Post-chemotherapy In Women with early-stage breast cancer (CHAMPION)

Princess Margaret Cancer Centre
Project: External validation of the VIGEX gene-expression signature as a novel predictive biomarker for immuneoncology (IO) treatments

Sunnybrook Health Sciences Centre
Project: Towards a Better Therapeutic Ratio: The Role of Magnetic Resonance-Linear Accelerator (MR-Linac) in Radiotherapy

Princess Margaret Cancer Centre
Project: Seeing Clearly: A Decision Analysis of MRI, PSMA PET/CT, and Biomarker Testing in Early Prostate Cancer Detection

The Hospital for Sick Children
Project: PICTURE: PARP Inhibitors and Chemotherapy for patients harbouring TUmours with homologous REcombination repair deficiency: a phase II pilot study

Mount Sinai Hospital
Project: Clinicopathologic and Molecular Predictors of Outcomes Following Salvage Surgery for Locally Recurrent Rectal Cancer 

Princess Margaret Cancer Centre
Project: Fragility Index of Approved Cancer Drugs 

Princess Margaret Cancer Centre
Project: ONCO-GEMINI: Oncology Continuum General Medicine Inpatient Initiative 

Mount Sinai Hospital
Project: Cardiac Outcomes in Pregnant Cancer Survivors: A Prospective Cohort Study

Princess Margaret Cancer Centre
Project: Immune Resistance Interrogation Study (IRIS): evaluating genomic, transcriptomic, epigenetic, immunophenotypic and radiomic profiles associated with primary and acquired resistance to PD1/PD-L1 targeting agents.

Sunnybrook Health Sciences Centre
Project: Early surrogate measures and predictors of outcome for intermediate risk prostate cancer patients treated with ablative therapies

SmartCentres Hold’em for Life Oncology Fellow
Princess Margaret Cancer Centre
Project: Predicting Outcomes in Pancreatic Cancer from Clinical and Genomic Data using Machine Learning

Toronto General Hospital 
Project: Enhancing sentinel lymph node mapping in lung cancer surgery using a novel liposome-based dual-modality nanoparticle 

CMCC/Atrium Hold’em for Life Oncology Fellow
Princess Margaret Cancer Centre
Project: Porphysomes for the intraoperative visualization of colorectal lymph node metastases

Princess Margaret Cancer Centre

Project: Impact of Proton Pump Inhibitors on prostate cancer diagnosis and outcomes 

CMCC/Atrium Hold’em for Life Oncology Fellow
Princess Margaret Cancer Centre
Project: Characterization of endometrioid carcinoma of the endometrium: molecular subtype assignment to infirm treatment decisions and improve outcomes 

RBC Hold'em for Life Oncology Fellow
The Hospital for Sick Children
Project: Re-envisioning the autologous hematopoietic stem cell transplant as immunotherapy

Sunnybrook Health Sciences Centre
Project: Adjuvant 5-aminolevulinic acid-based intraoperative photodynamic therapy of glioblastoma multiforme: A prospective pilot study

Princess Margaret Cancer Centre
Project: Clinical applications of free DNA in Multiple Myeloma 

The Hospital for Sick Children
Project: High-throughput drug screening and development of in vivo drug models for pineoblastoma

BMO Hold'em for Life Oncology Fellow
Mount Sinai Hospital
Project: Investigation of the Polo-like Kinas 4 Interactome as a Novel Therapeutic Target in Gastric Cancer

Katie Hoffman Hold’em for Life Oncology Fellow
Mount Sinai Hospital
Project: The Role of Hedgehog Signaling in Basal-Like Breast Cancer and the Tumor Microenvironment

Princess Margaret Cancer Centre
Project: Establishing national benchmarks and quality improvement priorities for the surgical care of kidney cancer patients in Canada

Dream Hold’em for Life Oncology Fellow
Women's College Hospital
Project: What are the determinants of breast cancer screening practices for women aged 40-49?

Toronto Western Hospital
Project: Establishing the utility of a novel plasma-based biomarker to non invasively prognosticate meningiomas

Levinsky Waratah Hold’em for Life Oncology Fellowship
Sunnybrook Health Sciences Centre
Project: Symptom Burden as a Predictor of Emergency Room Visits and Unplanned Hospitalizations in Patients with Head and Neck Cancer 

Princess Margaret Cancer Centre
Project: Evaluation of the tumour-adjacent microbiota in patients with metastatic genitourinary (GU) cANcers: the URinary and fecal microBiome (URBAN)

Silverberg Hold’em for Life Oncology Fellow
Princess Margaret Cancer Centre
Project: Photodynamic Therapy during in vivo lung perfusion for treatment of lung metastases 

Princess Margaret Cancer Centre
Project: Characterizing mechanisms of response and resistance to binimetinib and encorafenib in advanced cancers with non- V600E BRAF mutations: correlative analyses of the BEAVER trail 

Mount Sinai Hospital
Project: Circulating Tumor DNA Detection in Soft Tissue Sarcoma (DNATSAR)

Princess Margaret Cancer Centre
Project: Feasibly Integrating Epigenomic and Genomic Liquid Biopsy Biomarkers  

The Hospital for Sick Children
Project: Mitochondrial Fission: Targeting the Achilles' Heel of Glioblastoma 

The Gerald Schwartz & Heather Reisman Foundation Hold'em For Life Oncology Fellow
Princess Margaret Cancer Centre
Project: Application of the Generalizable Frailty Index using population-based health administrative data in older patients with diffuse large B-cell lymphoma (DLBCL), with further sensitivity analyses using a smaller cohort with detailed pathologic and cancer-specific data 

Toronto Western Hospital
Project: Liquid biopsy of gliomas by absolute quantification of IDH mutation

Princess Margaret Cancer Centre
Project: Measurement of psychometric properties of the Functional Assessment of Cancer Therapy – Immune Checkpoint Modulators (FACT-ICM) health related quality of life tool in patients treated with durvalumab and oleclumab in various solid tumors

Princess Margaret Cancer Centre
Project: Evaluating the Integrative Role of Regulatory T Cells, Myeloid-Derived Suppressor Cells, Inflammatory Cytokines and Neutrophil-Lymphocyte Ratio as Biomarkers of Response and Toxicity in Patients with Advanced Stage Cancer Treated with Pembrolizumab 

CIBC Capital Markets Hold’em for Life Oncology Fellow
Princess Margaret Cancer Centre
Project: Identifying molecular vulnerabilities in pancreatic cancer 

The Hospital for Sick Children
Project: Exploring the spectrum of cell identities and treatment vulnerabilities in K27M pediatric gliomas

Mount Sinai Hospital
Project: Toward Streamlining Colon Cancer Care 

Toronto General Hospital
Project: Characterizing Heart And Mind health Post-chemotherapy In Women with early-stage breast cancer (CHAMPION)

Sunnybrook Health Sciences Centre
Project: Development and external validation of a personalized model to predict survival in esophageal cancer patients 

SmartCentres Hold’em for Life Oncology Fellow
Mount Sinai Hospital
Project: Transforming care for high-risk muscle-invasive bladder cancer using fast-tracked new MRI techniques and radiomics to decrease time to cystectomy 

Princess Margaret Cancer Centre

Project: Impact of Proton Pump Inhibitors on prostate cancer diagnosis and outcomes 

BMO Hold'em for Life Oncology Fellow
Mount Sinai Hospital
Project: Investigation of the Polo-like Kinas 4 Interactome as a Novel Therapeutic Target in Gastric Cancer

Katie Hoffman Hold’em for Life Oncology Fellow
Mount Sinai Hospital
Project: The Role of Hedgehog Signaling in Basal-Like Breast Cancer and the Tumor Microenvironment

Mount Sinai Hospital
Project: Investigation and Design of Oncolytic Vaccinia Virus-Based Therapies in Colorectal Cancer

Sunnybrook Health Sciences Centre
Project: Liquid biopsy of brain tumours using MR-guided focused ultrasound-induced blood-brain barrier disruption 

Dream Hold’em for Life Oncology Fellow
Women's College Hospital
Project: What are the determinants of breast cancer screening practices for women aged 40-49?

CentreCourt Hold’em for Life Oncology Fellow
Princess Margaret Cancer Centre
Project: Comparison of OpeN VErsus RoboTic (CONVERT) Partial Nephrectomy Trial- a feasibility randomized control trial

Toronto Western Hospital
Project: Establishing the utility of a novel plasma-based biomarker to non invasively prognosticate meningiomas 

Princess Margaret Cancer Centre
Project: Evaluation of the tumour-adjacent microbiota in patients with metastatic genitourinary (GU) cANcers: the URinary and fecal microBiome (URBAN)

Mount Sinai Hospital
Project: Early Advance Care Planning in Hematologic Malignancies and Hematopoietic Stem Cell Transplants: A Pre-Post Pilot Study 

Princess Margaret Cancer Centre
Project: Feasibly Integrating Epigenomic and Genomic Liquid Biopsy Biomarkers